Date
March 10-13, 2023Date
March 10-13, 2023Date
March 10-13, 2023Date
March 10-13, 2023WHAT'S ABOUT EVENT
Join Scantox and expert collaborators for a full-day scientific symposium focused on accelerating discovery and development in neurodegenerative disease research. Explore how integrated in vitro and in vivo models—paired with emerging biomarkers—are transforming translational success in Alzheimer’s, Parkinson’s, ALS, and rare disorders.
Whether you're advancing early-stage discovery, selecting efficacy models, or planning IND-enabling studies, this event delivers practical insights, scientific depth, and collaborative dialogue in an intimate academic setting.
DONATION / meet with greaters
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WHO SHOULD ATTEND
This symposium is designed for scientists and leaders working in CNS discovery and translational research, including:
- Neuroscientists advancing early discovery programs in Alzheimer’s, Parkinson’s, ALS, and rare diseases
- Drug developers planning IND-enabling studies or evaluating translational models and biomarkers
- Preclinical R&D professionals from biotech, pharma, regulatory consulting and academia focused on neurodegeneration and CNS therapeutics
(Please note: this meeting is intended for professionals directly involved in CNS drug discovery and development to ensure discussions remain focused and valuable.)
Symposium Agenda


Session 1: From Trends to Translation – Discovery Pharmacology for Alzheimer’s and Parkinson’s Therapies
This session will outline strategies for model selection based on therapeutic modality, target class, and mechanism of action, highlighting in vitro and in vivo systems for Alzheimer’s and Parkinson’s disease, and discussing how translational model design and data interpretation can strengthen early-stage CNS development.

This session will examine neurofilament light chain (NF-L) as a sensitive marker of axonal damage and its application across species and sample types, highlighting NF-L measurement in cell culture models and in vivo rodent systems, with examples spanning Alzheimer’s, Parkinson’s, ALS, and lysosomal storage disorders. Discussion will focus on how NF-L enables longitudinal tracking of neurodegeneration from preclinical models to patients.


This session will explore next-generation therapeutic strategies and biomarkers in Parkinson’s disease. It will review current treatment approaches and highlight novel targets from the MJFF Targets to Therapies initiative, including mitochondrial dysfunction, endolysosomal proteins, and neuroinflammation. The discussion will also cover key neurodegeneration markers and how in vitro systems and rodent models are advancing preclinical PD research.

Case Study: In Vivo Application of Extracellular Vesicle-Based Genome Editing Technology
This session will feature a case study with from Evox Therapeutics, sharing how collaboration with Scantox Neuro supported rapid efficacy testing in preclinical neuroscience. This talk will review the rationale behind model selection, showcase translational outcomes, and reflect on key lessons learned that can inform future CNS drug development programs.


This session will explore the use of defined and consistent human cell systems to model neurodegeneration. It will show how scalable, reproducible populations carrying disease-relevant mutations can improve mechanistic studies, enable robust comparisons across experiments, and accelerate drug discovery workflows in CNS research.


This session will highlight the Göttingen Minipig as a versatile large-animal model in drug discovery and development. It will explore opportunities for modeling CNS and metabolic indications while also drawing on extensive experience in local tolerance studies. Discussion will focus on the advantages of the minipig for translational relevance, administration across multiple routes, and its growing role in bridging discovery to regulatory studies.

Q&A Panel Discussion
Focused Q&A with experts answering audience questions and providing actionable, candid insights.

Closing Remarks & Networking
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THE VENUE
Graduate by Hilton Cambridge
Granta Pl, Mill Ln, Cambridge
CB2 1RT, United Kingdom
+441223259988
marketing@scantox.com
CB2 1RT, United Kingdom
+441223259988
marketing@scantox.com
REGISTER TODAY
Reserve your spot by submitting the registration form below.
Reserve your spot by submitting the registration form below.