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October 13, 2026

Scantox Neuro Symposium Boston

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October 13, 2026

Scantox Neuro Symposium Boston

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  • Minutes
  • Seconds
REGISTER

Date

March 10-13, 2023

Date

March 10-13, 2023

Date

March 10-13, 2023

Date

March 10-13, 2023

ABOUT THE EVENT

Join Scantox and invited scientific experts for a half-day symposium exploring current approaches to modeling neurodegenerative diseases across the preclinical discovery pipeline. Examine how neuroinflammation, shared biomarker networks, lysosomal dysfunction, human-relevant NAMs, advanced in vitro systems, and established in vivo models can be integrated to strengthen translational research in Alzheimer’s, Parkinson’s, and related neurological disorders.

Whether you are investigating disease mechanisms, selecting appropriate models, evaluating translational biomarkers, or advancing an early-stage therapeutic program, this event will deliver practical insights into building integrated preclinical strategies that support stronger scientific decisions and reduce development risk.

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WHO SHOULD ATTEND

This symposium is designed for scientists and leaders working across CNS discovery, preclinical development, and translational research, including:

  • Neuroscientists investigating neuroinflammation, lysosomal dysfunction, disease mechanisms, and shared pathological pathways in Alzheimer’s, Parkinson’s, and related neurodegenerative disorders
  • Drug discovery teams evaluating human-relevant NAMs, advanced in vitro systems, in vivo models, and translational biomarkers
  • Preclinical R&D professionals from biotechnology, pharmaceutical companies, regulatory consulting, and academia seeking to strengthen model selection, efficacy assessment, and translational decision-making

(Please note: this meeting is intended for professionals directly involved in CNS drug discovery and development to ensure discussions remain focused and valuable.)

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Symposium Agenda

Lone Bruhn Madsen
09:00 - 09:15

Opening Remarks

Lone Bruhn Madsen, PhD | CSO, Discovery at Scantox
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09:15 - 09:45

Session 1: Modeling Neuroinflammation Across Neurodegenerative Diseases: From Cellular Mechanisms to Translational Readouts

This session will outline approaches for modeling neuroinflammation across neurodegenerative diseases, highlighting in vitro and in vivo systems for investigating microglial activation, astrocyte responses, immune-cell infiltration, cytokine signaling, and phagocytosis, and discussing how complementary biochemical, histological, cellular, and molecular readouts can strengthen mechanistic and translational research.

Stefan Ebner-Benke, PhD, MBA | Director, In Vivo at Scantox Neuro
Lone Bruhn Madsen
09:45 - 10:05

Session 2a: The Göttingen Minipig in Drug Discovery and Development - Applying the Model in an Obesity Context

This session will examine the Göttingen Minipig as a translational large-animal model, using obesity research to illustrate its application across pharmacology, CNS development, PK/PD assessment, and regulatory toxicology, and discussing how flexible administration routes, longitudinal sampling, biomarker evaluation, and clinically relevant pharmacokinetic data can support progression from discovery through preclinical development.

Lone Bruhn Madsen, PhD | CSO, Discovery at Scantox Group
Tina Loeffler PhD - Scantox
10:05 - 10:25

Session 2b: Shared Biomarker Networks Across Models of Neurodegeneration and Lysosomal Dysfunction

This session will examine shared and disease-specific biomarker patterns across mouse models of Alzheimer’s disease, Parkinson’s disease, and lysosomal storage disorders, highlighting changes in protein aggregation, neuroinflammation, lysosomal function, synaptic integrity, and cellular senescence, and discussing how comparative biomarker profiling can strengthen model selection, mechanistic investigation, and translational drug discovery.

Tina Löffler, PhD | Director, Cellular and Translational Science at Scantox Neuro
Tina Loeffler PhD - Scantox
11:00 - 11:30

Session 3: Bridging Mechanism to Efficacy: Integrating NAMs with In Vivo Models to De-risk Alzheimer’s and Parkinson’s Drug Discovery

This session will outline strategies for model selection based on therapeutic modality, target biology, and mechanism of action, highlighting mechanistic assays, human iPSC-derived systems, advanced 3D Neurospheres, and established in vivo models for Alzheimer’s and Parkinson’s disease, and discussing how integrated model cascades and data interpretation can strengthen early-stage decisions and reduce development risk.

Tina Löffler, PhD | Director, Cellular and Translational Science at Scantox Neuro
Thierry Bussiere
11:30 - 12:00

Developing a New Molecule for the Treatment of Alzheimer's Disease: Choosing the Appropriate Mouse Models to Reliably Inform Human Endpoints

Using the development of aducanumab as a case study, this session will examine how Alzheimer’s disease mouse models have evolved and why model selection should be driven by the human endpoints a program needs to inform. It will explore how different models address distinct translational questions, how mouse data should be interpreted against clinically relevant outcomes, and the inherent limitations of current AD models.

Thierry Bussiere | Alzheimer's Disease Drug Development Consultant
2025-10, PRC - LI
12:00 - 12:10

Closing Remarks

Priyanka Chanana, PhD | Business Development Director at Scantox Neuro
lunch at the Grad Cam
12:10 - 13:00

Lunch & Networking

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